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ABOUT TYPE 2 DIABETES

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A GROWING GLOBAL HEALTH CRISIS

More than 350MM people globally living with type 2 diabetes
Diabetes is the leading cause of kidney failure, lower-limb amputations & blindness in adults
Average annual medical expenditure > 2.3x higher for diabetics

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MAJORITY OF PATIENTS ARE NOT ACHIEVING TREATMENT GOALS

> $35Bn annual market for type 2 diabetes medical therapies
• Average type 2 patient is on more than
6 prescription medications
Fewer than 50% of patients achieve target HbA1c

CHALLENGES TO MAINTAINING OPTIMAL MEDICAL THERAPY

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Polypharmacy result in regular tolerability issues for more than 70% of patients
Clinical inertia delays therapy progression in 50+% of patients
Only ~40% of patients are compliant with medical therapy after 12-24 months

Home: About T2DM

A NEW PATH TO METABOLIC HEALTH

The small intestine plays a key role in regulating metabolic processes and insulin resistance.  Studies have shown that up to 90% of patients who undergo bariatric surgery with duodenal exclusion achieve improved insulin resistance and glycemic control.

Digma aims to harness the power of the duodenum to empower patients and physicians with safe, simple and effective new therapies for type 2 diabetes that enable them to live longer, healthier and happier lives.

We are developing a minimally invasive therapy, Endoscopic Glycemic Management (EGM), that aims to restore the body’s natural ability to control blood glucose levels.  The treatment targets the duodenal submucosa which is central to nutrient sensing and metabolic signaling.


Our product consists of a console and a single-use catheter that is compatible with the working channel of standard gastrointestinal endoscopes. The EGM procedure is being developed so that it can be performed in a standard GI endoscopy suite without requiring additional imaging equipment.  Our goal is to provide patients with durable improvement in glycemic control with minimal side effects and without requiring additional daily medical therapy.


The EGM procedure  is currently being evaluated in clinical studies.  To learn more about our clinical program, please contact us here.

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LEADERSHIP TEAM

Ilan brings more than 20 years of experience in R&D and management in the medical device industry.  In addition to co-founding Digma, he served as founder and CTO of Eximo Medical (acquired by AngioDynamics), was the CTO of Exalenz Bioscience Ltd., (acquired by Meridian BioScience) and was CTO at Oridion Medical (acquired by Covidien).  Ilan is the author of more than 40 patents and patent applications in the field of medical technologies and electro-optics. Mr. Ben-Oren holds a master’s degree in applied physics and the science of materials summa cum laude from the Hebrew University of Jerusalem.

ILAN BEN-OREN

Co-founder and CTO

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Shlomit  joined Digma Medical as VP of R&D in 2021 and brings more than 15 years of R&D management experience, including leading multidisciplinary teams in the development of Class II and III medical devices from early prototype to formal product development and through manufacturing transfer.  Previously, Shlomit served as VP R&D at Nano-Dimension Technologies and in roles of increasing responsibility at Edwards Life Sciences and Medinol Ltd.  Dr. Chappel-Ram holds a BSc (Summa Cum Laude) in Physical Chemistry, Ph.D. (Summa Cum Laude) specialized in Photo-electrochemistry and Materials Science and a MBA from Bar-Ilan University, Israel.

SHLOMIT CHAPPEL-RAM, PhD

Vice President, R&D

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Hila has over 10 years of experience in medical device regulatory, clinical affairs and quality assurance.  Prior to Digma, Hila was Vice President, Clinical and Regulatory Affairs in a wearable telemedicine startup where she built and led the regulatory strategy, clinical affairs and quality system infrastructure.  Prior to that, Hila was a researcher and project manager in other medical device companies in the field of wound care and stem cells regenerative medicine.  Dr. Dagan holds a PhD in Biotechnology from Tel Aviv University in the field of nano-biotechnology, an M.Sc. from Tel Aviv University and a B.Sc. in biology from The Hebrew University of Jerusalem.

HILA DAGAN, PhD

Vice President,

Regulatory, Clinical and Quality

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Brian brings over 25 years of clinical and research experiences within the endocrinology, diabetes and metabolism community.  Prior to Digma, he served as CMO & Worldwide VP of Clinical Affairs of Johnson & Johnson Diabetes Care Companies where he oversaw all of clinical and medical affairs of the group.  Before that, he served as Global Medical Affairs Leader for Metabolic Disease at Janssen Pharma, where he led the INVOKANA (canagliflozin) medical affairs program. Dr. Levy was on faculty at NYU School of Medicine, where he remains an attending physician at Bellevue Hospital. He received his B.A. at Cornell University, his M.D. from Johns Hopkins University School of Medicine, and completed his residency & fellowship in Endocrinology & Metabolism at NYU Medical Center.

BRIAN L. LEVY, MD, FACE

Medical Director

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Home: Our Team

BOARD OF DIRECTORS

Mori Arkin

Arkin Holdings

Irit Yaniv, MD
Chairwoman of the Board
AccelMed & Co-founder, Digma Medical

Ilan Ben-Oren

Co-founder & CTO, Digma Medical

Eyal Dior
Tal Ventures

Anat Tsour Segal

CBG Ventures

James McNally
Independent Director

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INVESTORS

Digma Medical is a privately held company backed by these leading venture capital firms

Accelmed
Arkin Holdings
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Peregrine
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